Catherine de Medicis  (Royal Medicis Family of Italy)

* Neice of Pope Clement VII
* In 1533, married Henry de Valois (Henry II)
* Rumors of disease and mental illness started, when for 10 years, no children  were born to this royal couple. Some blamed 
    an inherent disability in Catherine, since both her parents had died of Syphillis within 22 days of her birth. After 10 years 
    though, children came annually, 10 in all. 3 died at an early age. 3 became kings, two were queens. Although Catherine 
    outlived her husband and 3 successive royal sons, her children were all diseased or mentally ill. (Bk-1, 139)

Proceed on to Henry de Valois (King Henry II of Northern France)